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서영미 ( Seo Young-Mi ) - 전주대학교 간호학과
정석희 ( Jeong Seok-Hee ) - 전북대학교 간호대학
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Abstract
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Purpose: The purpose of this study was to evaluate the effects of essential oil on oxidative stress, immunity, and skin condition in atopic dermatitis (AD) induced mice.
Methods: This study was a 3×3 factorial design. Factors were oil type (Lavender, Thyme, and 2:1 mixture of lavender and thyme oil [blending oil]) and treatment period (0 day, 7 days, and 21 days). The samples were 45 mice with AD and randomly assigned to nine groups of five mice per group. The dependent variables such as superoxide radical, IgE, degranulated mast cells, and epidermal thickness were measured. Data were collected from February to April in 2014. Descriptive statistics, One-way ANOVA, Two-way ANOVA, and Tukey’s HSD test were performed using the SPSS WIN 20.0 program.
Results: Dependent variables were not statistically significantly different by the three oil types (p>.05). Essential oils such as lavender, thyme, and blending oil were all effective in reducing AD symptoms and especially 2:1 blending oil were most effective. There were statistically significant differences by the three treatment periods in all dependent variables (p<.001). There were statistically significant interactions between oil types and treatment periods in all dependent variables (p<.01). For decreasing superoxide radical, degranulated mast cells, and epidermal thickness, 2:1 mixed oil should be applied for at least 21 days. Otherwise to reduce IgE, 2:1 mixed oil should be used for at least 7 days.
Conclusion: These findings provide bases for developing effective interventions for AD patients to manage their AD symptoms.
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KeyWords
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아토피피부염 , 에센셜 오일 , 초산화 라디칼 , 면역글로블린 E , 비만세포
Atopic dermatitis , Essential oil , Superoxide radical , IgE , Mast cell
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원문 및 링크아웃 정보
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등재저널 정보
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